While the inflammation-reducing and fibrosis-attenuating effects of glucagon agonism are less well-characterized, the reductions in hepatic inflammation parameters and fibrosis observed in preclinical models likely reflect secondary effects consequent to improved steatosis, rather than direct anti-inflammatory actions [21]
Additionally, Al-Aly and his team reconfirmed a potential dementia-protecting benefit when they found participants taking GLP-1 drugs had a decreased risk of neurocognitive conditions such as dementia and Alzheimers disease
Another study found that psychiatric AEs only accounted for 1.2 % of total reports for semaglutide, liraglutide, and tirzepatide [47,48], although rare case reports have suggested suicide as a serious psychiatric AE of semaglutide 2.4 mg [[49], [50], [51], [52]]
Residents of Miami Beach considering a Zepbound prescription can benefit from these profound changes in their weight management efforts
This dual action on metabolism and appetite has made them particularly effective for weight management, with clinical trials demonstrating substantial weight loss in people with obesity
